Site web nou 1 » Summary

Colorectal cancer (CRC) is initiated by the formation of a benign polyp within the colon and rectum, which subsequently progresses to malignancy. The etiological and risk factors associated with the development of CRC are indicative of the complex and multifaceted nature of this disease. The absence of precise distinction in symptoms related to CRC highlights the significance of screening, prompting the development of various tests such as stool tests and colonoscopies over time; but the presence of blood in the stool is not a reliable diagnostic test for colorectal cancer, being also related to other diseases, while colonoscopy is quite an uncomfortable test.Electrochemical sensors offer a robust method for detecting colorectal cancer markers due to the combined advantages of high sensitivity in electrochemical analysis and the specificity inherent in biological reactions. Hence, the current project aims to develop novel electrochemical sensing platforms with the ability to detect extremely low concentrations of biomarkers for early diagnosis and monitor variations in biomarker concentration for disease prognosis, thereby providing insights into disease progression. The novelty of this project will consist in designing and validating of innovative 3D stochastic sensor platforms. These platforms will be utilized for the analysis of new panels of biomarkers combined with enantioanalysis, with the aim of facilitating early detection of CRC.